Pharmacology

Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Ondansetron comes as a solution (liquid) to be injected intravenously (into a vein) or intramuscularly (into a muscle) by a healthcare provider in a hospital or clinic. When ondansetron is used to prevent nausea and vomiting caused by chemotherapy, it is usually given 30 minutes before the start of chemotherapy.

Interactions

Phenytoin, and carbamazepine; to treat epilepsy, as these medicines may reduce the effect of Ondansetron Injection Antibiotics such as rifampicin or erythromycin, as these medicines may reduce the effect of Ondansetron Injection Ketoconazole, a medicine used to treat a fungal infection, Tramadol, a strong painkiller, as Ondansetron Injection may reduce the effect of tramadol Medicines used to treat an uneven heartbeat (arrhythmias), as these medicines may interact with Ondansetron Injection and affect the rhythm of the heart Cancer medicines (e.g. anthracyclines or trastuzumab), antibiotics (e.g. erythromycin), antifungals (e.g. ketoconazole), or other medicines which might disturb your heart rhythm

Precautions & Warnings

Talk to your doctor or pharmacist before receiving Ondansetron Injection if you have or have had prolonged QT interval (seen on an ECG, electrical recording of the heart), if you have or have had alterations in heart rhythm (including a slow or uneven heartbeat) or other heart problems (such as heart failure or conduction disorders) or, if you have problems with the levels of salts in your blood, such as potassium, sodium, and magnesium or, if you have liver problems or, if you have gut problems such as a blockage or suffer from severe constipation or, if you have just had or are going to have your adenoids or tonsils removed Keep out of reach of the children